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Article

RoboCOP: jointly computing chromatin occupancy profiles for numerous factors from chromatin accessibility data.

Nucleic acids research - 20 Aug 2021

Mitra Sneha, Zhong Jianling, Tran Trung Q, MacAlpine David M, Hartemink Alexander J

Abstract excerpt

Chromatin is a tightly packaged structure of DNA and protein within the nucleus of a cell. The arrangement of different protein complexes along the DNA modulates and is modulated by gene expression. Measuring the binding locations and occupancy levels of different transcription factors (TFs) and nucleosomes is therefore crucial to understanding gene regulation. Antibody-based methods for assaying chromatin...

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Identifiers

PMID: 34255854
DOI: 10.1093/nar/gkab553
PMCID: PMC8373080

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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