Article

A nucleotide resolution map of Top2-linked DNA breaks in the yeast and human genome

2019-01-26

Abstract excerpt

DNA topoisomerases are required to resolve DNA topological stress. Despite this essential role, abortive topoisomerase activity generates aberrant protein-linked DNA breaks, jeopardising genome stability. Here, to understand the genomic distribution and mechanisms underpinning topoisomerase-induced DNA breaks, we map Top2 DNA cleavage with strand-specific nucleotide resolution across the S. cerevisiae and human g...

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Literature Corpus work: 7bfa6588-c759-5231-a5c4-47079c65af61
DOI: 10.1101/530667

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