Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Topoisomerase II beta interacts with cohesin and CTCF at topological domain borders.

Genome biology - 31 Aug 2016

Uusküla-Reimand Liis, Hou Huayun, Samavarchi-Tehrani Payman, Rudan Matteo Vietri, Liang Minggao, Medina-Rivera Alejandra, Mohammed Hisham, Schmidt Dominic, Schwalie Petra, Young Edwin J, Reimand Jüri, Hadjur Suzana, Gingras Anne-Claude, Wilson Michael D

Abstract excerpt

BACKGROUND: Type II DNA topoisomerases (TOP2) regulate DNA topology by generating transient double stranded breaks during replication and transcription. Topoisomerase II beta (TOP2B) facilitates rapid gene expression and functions at the later stages of development and differentiation. To gain new insight into the genome biology of TOP2B, we used proteomics (BioID), chromatin immunoprecipitation, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CCCTC-Binding Factor
Share to Chromatin Immunoprecipitation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chromosomal Proteins, Non-Histone

Share to Chromosomes

Share to Cohesins

Share to DNA Topoisomerases, Type II

Share to Poly-ADP-Ribose Binding Proteins

Share to Protein Interaction Maps

Source

Open in PubMed Open full text

Identifiers

PMID: 27582050
DOI: 10.1186/s13059-016-1043-8
PMCID: PMC5006368

Genes

CTCF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Topoisomerase II beta interacts with cohesin and CTCF at topological domain borders.PMID 27582050Read ↗

Genome-wide prediction of topoisomerase II <i>β</i> binding by architectural factors and chromatin accessibilitySemantic proximity Read ↗

Topoisomerase IIb binding underlies frequently mutated elements in cancer genomesSemantic proximity Read ↗

Human topoisomerases and their roles in genome stability and organizationSemantic proximity Read ↗

A nucleotide resolution map of Top2-linked DNA breaks in the yeast and human genomeSemantic proximity Read ↗

A nucleotide resolution map of Top2-linked DNA breaks in the yeast and human genomeSemantic proximity Read ↗

Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instabilitySemantic proximity Read ↗

Topoisomerase II binds nucleosome-free DNA and acts redundantly with topoisomerase I to enhance recruitment of RNA Pol II in budding yeast.Semantic proximity Read ↗

TOPBP1 recruits TOP2A to ultra-fine anaphase bridges to aid in their resolution.Semantic proximity Read ↗

Topoisomerase II regulates yeast genes with singular chromatin architectures.Semantic proximity Read ↗

Topological regulation of the estrogen transcriptional response by ZATT-mediated inhibition of TOP2B activitySemantic proximity Read ↗

When TADs go bad: chromatin structure and nuclear organisation in human diseaseSemantic proximity Read ↗

DNA Topoisomerase I differentially modulates R-loops across the human genomeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.