Article

A hierarchical Bayesian framework for inferring mitochondrial clonal selection from single-cell data

2026-02-12

Abstract excerpt

<title>Abstract</title> <p>Mitochondrial genetic heterogeneity arises from the accumulation of somatic mitochondrial DNA (mtDNA) mutations within individual cells, generating intracellular clonal populations whose selective dynamics in disease remain poorly characterized. Here, we present MitoBayes, a hierarchical Bayesian framework that jointly models mitochondrial clonal lineage structure, allele frequency vari...

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Literature Corpus work: d681d22c-a8e7-5e06-b37b-937b2a6c8e9c
DOI: 10.21203/rs.3.rs-8490828/v1

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