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Article

Clonal expansion dictates the efficacy of mitochondrial lineage tracing in single cells.

Genome biology - 26 Mar 2025

Wang Xin, Wang Kun, Zhang Weixing, Tang Zhongjie, Zhang Hao, Cheng Yuying, Zhou Da, Zhang Chao, Zhong Wen-Zhao, Ma Qing, Xu Jin, Hu Zheng

Abstract excerpt

BACKGROUND: Mitochondrial DNA (mtDNA) variants hold promise as endogenous barcodes for tracking human cell lineages, but their efficacy as reliable lineage markers are hindered by the complex dynamics of mtDNA in somatic tissues. RESULTS: Here, we use computational modeling and single-cell genomics to thoroughly interrogate the origin and clonal dynamics of mtDNA variants across various biological settings. Our...

Read the complete abstract on PubMed

Topics

Humans
Single-Cell Analysis
Cell Lineage
DNA, Mitochondrial
Mitochondria
Mutation

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Identifiers

PMID: 40134031
DOI: 10.1186/s13059-025-03540-7
PMCID: PMC11938731

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