Article

MiTo: tracing the phenotypic evolution of somatic cell lineages via mitochondrial single-cell multi-omics

2025-06-20

Abstract excerpt

Mitochondrial single-cell lineage tracing (MT-scLT) has recently emerged as a scalable and non-invasive tool to trace somatic cell lineages. However, the reliability and resolution of MT-scLT remains highly debated. Here, we present MiTo , the first end-to-end framework for robust MT-scLT data analysis. Thanks to highly-optimized algorithms and user-friendly interfaces, this modular toolkit offers unprecedented c...

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Literature Corpus work: 0fe65fe3-5617-5f26-8cf9-ee7224614b31
DOI: 10.1101/2025.06.17.660165

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