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PHALCON: phylogeny-aware variant calling from large-scale single-cell panel sequencing datasets

2025-08-05

Abstract excerpt

<title>Abstract</title> <p>Single-cell sequencing (SCS) enables variant detection and tumor phylogeny reconstruction for resolving intra-tumor heterogeneity (ITH), which causes drug resistance and cancer relapse. Recently emerged panel sequencing methods sequence disease-specific genes across thousands of cells, but existing variant callers and SCS-specific phylogenetic methods struggle with large-scale datasets...

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Literature Corpus work: 6fca0e11-8390-59f7-a5f3-91d4acfd8bb4
DOI: 10.21203/rs.3.rs-6155560/v1

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