Article

Robustness and reliability of single-cell regulatory multi-omics with deep mitochondrial mutation profiling

2024-08-24

Abstract excerpt

The detection of mitochondrial DNA (mtDNA) mutations in single cells holds considerable potential to define clonal relationships at scale, coupled with information on cell state in humans. Previous methods focused on higher heteroplasmy mutations, which, while informative, are few in number and may be shaped by functional selection, providing limited lineage information and potentially introducing biases for traci...

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Literature Corpus work: ed43bbce-73d9-55d3-8de2-37fa7dc08b64
DOI: 10.1101/2024.08.23.609473

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