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Article

Longitudinal Single-Cell Dynamics of Chromatin Accessibility and Mitochondrial Mutations in Chronic Lymphocytic Leukemia Mirror Disease History.

Cancer discovery - 1 Dec 2021

Penter Livius, Gohil Satyen H, Lareau Caleb, Ludwig Leif S, Parry Erin M, Huang Teddy, Li Shuqiang, Zhang Wandi, Livitz Dimitri, Leshchiner Ignaty, Parida Laxmi, Getz Gad, Rassenti Laura Z, Kipps Thomas J, Brown Jennifer R, Davids Matthew S, Neuberg Donna S, Livak Kenneth J, Sankaran Vijay G, Wu Catherine J

Abstract excerpt

While cancers evolve during disease progression and in response to therapy, temporal dynamics remain difficult to study in humans due to the lack of consistent barcodes marking individual clones in vivo. We employ mitochondrial single-cell assay for transposase-accessible chromatin with sequencing to profile 163,279 cells from 9 patients with chronic lymphocytic leukemia (CLL) collected across disease course and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Clone Cells

Share to DNA Copy Number Variations

Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Source

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Identifiers

PMID: 34112698
DOI: 10.1158/2159-8290.CD-21-0276
PMCID: PMC8660953

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