Article

Somatic mitochondrial DNA mutations are a source of heterogeneity among primary leukemic cells

2024-09-27

Abstract excerpt

Somatic mitochondrial DNA (mtDNA) mutations are prevalent in tumors, yet defining their biological significance remains challenging due to the intricate interplay between selective pressure, heteroplasmy, and cell state. Utilizing bulk whole-genome sequencing data from matched tumor and normal samples from two cohorts of pediatric cancer patients, we uncover differences in the accumulation of synonymous and nonsyn...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d627998b-59af-5e17-b0d8-3510d8cea972
DOI: 10.1101/2024.09.26.24314381

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Somatic mitochondrial DNA mutations are a source of heterogeneity among primary leukemic cellsDOI 10.1101/2024.09.26.24314381Read

Single-cell multi-omics of mitochondrial DNA disorders reveals dynamics of purifying selection across human immune cells.Semantic proximity Read

Deleterious heteroplasmic mitochondrial mutations increase risk of overall and cancer-specific mortalitySemantic proximity Read

Single-cell multi-omics reveals dynamics of purifying selection of pathogenic mitochondrial DNA across human immune cellsSemantic proximity Read

Deleterious heteroplasmic mitochondrial mutations are associated with an increased risk of overall and cancer-specific mortality.Semantic proximity Read

Heteroplasmic shifts in tumor mitochondrial genomes reveal tissue-specific signals of relaxed and positive selection.Semantic proximity Read

A hierarchical Bayesian framework for inferring mitochondrial clonal selection from single-cell dataSemantic proximity Read

scMitoMut for calling mitochondrial lineage–related mutations in single cellsSemantic proximity Read

Longitudinal Phylogenetic Inference of Copy Number Alterations and Single Nucleotide Variants from Single-Cell SequencingSemantic proximity Read

Single-cell multi-omic analysis of mitochondrial mutational mosaicism and dynamics.Semantic proximity Read

Inferring clonal evolution of tumors from single nucleotide somatic mutations.Semantic proximity Read

Massively parallel single-cell mitochondrial DNA genotyping and chromatin profiling.Semantic proximity Read

Single-cell multi-omics resolved analysis of mitochondrial genome-wide mutational burden, constraint, and mosaicismSemantic proximity Read