Article

Probabilistic cell lineage inference from mitochondrial mutations

2025-03-05

Abstract excerpt

Tissues and organs develop from single founder cells, which give rise to distinct cell lineages that contribute to regeneration and maintenance of homeostasis in the adult. Tracing the genealogical relationships between individual cells and their gene expression signatures is an important step towards understanding how these processes are regulated in human health and disease. Here, we present mt-SCITE, a computat...

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Literature Corpus work: 8d6eb0f7-a5dd-530b-ba85-848b42818fd5
DOI: 10.1101/2025.02.28.640740

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