Article

Clonal expansion dictates the efficacy of mitochondrial lineage tracing in single cells

2024-05-17

Abstract excerpt

Although mitochondrial DNA (mtDNA) variants hold promise as endogenous barcodes for tracking human cell lineages, their efficacy as reliable lineage markers is hindered by the complex dynamics of mtDNA in somatic tissues. Here, we utilized computational modeling and single-cell genomics to thoroughly interrogate the origin and clonal dynamics of mtDNA lineage markers across various biological settings. Our finding...

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Literature Corpus work: 8857ecf4-9cc5-5be7-ac23-6018ebe382bd
DOI: 10.1101/2024.05.15.594338

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