Article

Single-cell multi-omics resolved analysis of mitochondrial genome-wide mutational burden, constraint, and mosaicism

2025-05-21

Abstract excerpt

<title>Abstract</title> <p>Mitochondria contain their own circular, multi-copy genome, encoding essential components of the mitochondrial respiratory chain vital for cellular metabolism. Mitochondrial DNA (mtDNA) mutations occur more frequently than nuclear mutations and are associated with various diseases. While single-cell sequencing has allowed analysis of mtDNA variant heteroplasmy, a holistic view of mtDNA...

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Literature Corpus work: 1aedb20a-0bee-58f2-8c1d-4e1530b6b3b9
DOI: 10.21203/rs.3.rs-6539733/v1

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