Article

LINE1 promotes nuclear compartmentalization to repress the 8-cell state in embryonic stem cells

2024-09-23

Abstract excerpt

<h4>Summary</h4> The family of LINE1 transposable elements underwent a massive expansion in mammalian genomes. While traditionally viewed as a mutagenic selfish element, recent studies point to roles for LINE1 in early mouse development, T cell quiescence and neurogenesis. Here we show that human LINE1 RNA is essential for self-renewal and identity of human embryonic stem cells (hESCs). Silencing of LINE1 using e...

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Literature Corpus work: 08eff82d-cad5-5d43-941a-b7c010a8d937
DOI: 10.1101/2024.09.22.614332

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