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Article

The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure.

PLoS genetics - 12 Sept 2008

Jones Brendan, Su Hui, Bhat Audesh, Lei Hong, Bajko Jeffrey, Hevi Sarah, Baltus Gretchen A, Kadam Shilpa, Zhai Huili, Valdez Reginald, Gonzalo Susana, Zhang Yi, Li En, Chen Taiping

Abstract excerpt

Dot1 is an evolutionarily conserved histone methyltransferase specific for lysine 79 of histone H3 (H3K79). In Saccharomyces cerevisiae, Dot1-mediated H3K79 methylation is associated with telomere silencing, meiotic checkpoint control, and DNA damage response. The biological function of H3K79 methylation in mammals, however, remains poorly understood. Using gene targeting, we generated mice deficient for Dot1L,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 18787701
DOI: 10.1371/journal.pgen.1000190
PMCID: PMC2527135

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure.PMID 18787701Read ↗

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Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association.Semantic proximity Read ↗

Histone methyltransferase Dot1L plays a role in postembryonic development in Xenopus tropicalis.Semantic proximity Read ↗

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Epigenetic priming by Dot1l in lymphatic endothelial progenitors ensures normal lymphatic development and functionSemantic proximity Read ↗

Dot1p modulates silencing in yeast by methylation of the nucleosome core.Semantic proximity Read ↗

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Histone H3 Lysine 79 Methyltransferase Dot1 Is Required for Immortalization by MLL OncogenesSemantic proximity Read ↗

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