Article

AF10 (MLLT10) prevents somatic cell reprogramming through regulation of DOT1L-mediated H3K79 methylation

2020-12-22

Abstract excerpt

<h4>Summary</h4> The histone H3 lysine 79 (H3K79) methyltransferase DOT1L is a key chromatin-based barrier to somatic cell reprogramming. However, the mechanisms by which DOT1L safeguards cell identity and somatic-specific transcriptional programs remain unknown. Here, we employed a proteomic approach using proximity-based labeling to identify DOT1L-interacting proteins and investigated their effects on reprogram...

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Literature Corpus work: de369d9c-9d97-5bea-a9b8-889ddbef3388
DOI: 10.1101/2020.12.22.423908

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