Article

TET knockout cells transit between pluripotent states and exhibit precocious germline entry

2024-12-03

Abstract excerpt

<h4>Summary</h4> TET1, TET2 and TET3 are DNA demethylases with critical roles in development and differentiation. To assess the contributions of TET proteins to cell function during early development, single and compound knockouts of Tet genes in mouse pluripotent embryonic stem cells (ESCs) were generated. Here we show that TET proteins are not required to transit between naïve, formative and primed pluripotenc...

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Literature Corpus work: 5bffe232-4e14-5802-87a7-991059eb6aac
DOI: 10.1101/2024.12.02.626356

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