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H3K79 methylation and H3K36 tri-methylation synergistically regulate gene expression in pluripotent stem cells

2025-05-13

Abstract excerpt

In metazoans, nucleosomes harboring H3K79 methylation (H3K79me) deposited by the histone methyltransferase DOT1L decorate actively transcribed genes. Although DOT1L is implicated in transcription regulation and pathogenesis of human diseases such as leukemia and neurological disorders, the role of H3K79me in these biological processes remains elusive. Here, we reveal a novel functional synergism between H3K79me an...

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Literature Corpus work
65f8f419-865f-59d2-92a5-5e69802d9002
DOI
10.1101/2025.05.08.652740
Open publication

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H3K79 methylation and H3K36 tri-methylation synergistically regulate gene expression in pluripotent stem cellsDOI 10.1101/2025.05.08.652740
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