Article

Discovery of Competent Chromatin Regions in Human Embryonic Stem Cells

2023-06-14

Abstract excerpt

<h4>ABSTRACT</h4> The mechanisms underlying the ability of embryonic stem cells (ESCs) to rapidly activate lineage-specific genes during differentiation remain largely unknown. Through multiple CRISPR-activation screens, we discovered human ESCs have pre-established transcriptionally competent chromatin regions (CCRs) that support lineage-specific gene expression at levels comparable to differentiated cells. CCRs...

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Literature Corpus work: 73cbed80-ecfe-59c2-ae2a-10fd5878dd6c
DOI: 10.1101/2023.06.14.544990

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