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The activation of a <i>Suv39h1</i> -repressive antisense lncRNA by OCT4 couples the control of H3K9 methylation to pluripotency

2021-09-07

Abstract excerpt

Histone H3 Lysine 9 (H3K9) methylation, a characteristic mark of heterochromatin, is progressively implemented during development to contribute to cell fate restriction as differentiation proceeds. For instance, in pluripotent mouse Embryonic Stem (ES) cells the global levels of H3K9 methylation are rather low and increase only upon differentiation. Conversely, H3K9 methylation represents an epigenetic barrier for...

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Literature Corpus work
f27d8df9-b624-5e73-940d-687a66e2bd54
DOI
10.1101/2021.09.07.459323
Open publication

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