Article

Dot1L methyltransferase activity is a barrier to acquisition of pluripotency but not transdifferentiation

2019-11-07

Abstract excerpt

<h4>ABSTRACT</h4> The ability of pluripotent stem cells to be poised to differentiate into any somatic cell type is partly derived from a unique chromatin structure that is depleted for transcriptional elongation associated epigenetic modifications, primarily H3K79 methylation. Inhibiting the H3K79 methyltransferase, Dot1L, increases the efficiency of reprogramming somatic cells to induced pluripotent stem cells...

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Literature Corpus work: 78ce2e48-4a5c-5ba0-9501-1f8841f156ea
DOI: 10.1101/835413

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