Article

Phasing single-molecule nano-NOMe-seq reveals chromatin state heterogeneity in the context of transcription and long-range interactions

2025-09-09

Abstract excerpt

<h4>ABSTRACT</h4> A central challenge in molecular biology is determining how 3D chromatin architecture, particularly enhancer-promoter looping and insulating CTCF-mediated interactions, influences gene transcription in individual cells, which has significant implications for healthy and diseased states. To overcome current limitations in imaging and genomic technologies, we developed a cluster-based phasing stra...

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Literature Corpus work: d47c7c1d-c528-5e5e-a32f-45128a197d9a
DOI: 10.1101/2025.09.08.674887

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