Article

A Biophysical Framework to Decode Single-Molecule Chromatin Occupancy from Footprinting Data

2025-05-26

Abstract excerpt

<title>Abstract</title> <p>Gene regulation in eukaryotes emerges from a dynamic interplay between transcription factors (TFs), nucleosomes, and RNA Polymerase II (Pol II), whose competitive and cooperative binding shapes DNA accessibility and transcriptional output. Single-molecule footprinting (SMF) and long-read chromatin accessibility assays such as Fiber-seq now capture these interactions at nucleotide resolu...

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Literature Corpus work: 6535965b-5b55-5095-8f0b-f76ae0d6dbd3
DOI: 10.21203/rs.3.rs-6688228/v1

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