Article
O-SNAP: A comprehensive pipeline for spatial profiling of chromatin architecture
2025-07-23
Abstract excerpt
We present O-SNAP (Objective Single-Molecule Nuclear Architecture Profiler), a comprehensive pipeline for the automated extraction, comparison, and classification of nuclear features from single-molecule localization microscopy (SMLM) data. O-SNAP quantifies 144 interpretable, biologically grounded spatial features describing chromatin organization or histone mark distributions at nanoscale resolution. The pipelin...
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Identifiers and source
- Literature Corpus work
- 9b188db3-2188-59f4-b5e2-2e1834c00ae2
- DOI
- 10.1101/2025.07.18.665612