Article

Minimalistic 3D Chromatin Models: Sparse Interactions in Single Cells Drive the Chromatin Fold and Form Many-Body Units

2021-08-09

Abstract excerpt

Computational modeling of 3D chromatin plays an important role in understanding the principles of genome organization. We discuss methods for modeling 3D chromatin structures, with focus on a minimalistic polymer model which inverts population Hi-C into high-resolution, high-coverage single-cell chromatin conformations. Utilizing only basic physical properties such as nuclear volume and no adjustable parameters, t...

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Literature Corpus work: ad8277cc-1fa2-5bb3-90c7-61b393eb9a5f
DOI: 10.1101/2021.08.06.455444

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