Article

Transcriptional decomposition reveals active chromatin architectures and cell specific regulatory interactions

2017-04-24

Abstract excerpt

<h4>ABSTRACT</h4> Transcriptional regulation is tightly coupled with chromosomal positioning and three-dimensional chromatin architecture. However, it is unclear what proportion of transcriptional activity is reflecting such organisation, how much can be informed by RNA expression alone, and how this impacts disease. Here, we develop a transcriptional decomposition approach separating the proportion of expression...

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Literature Corpus work: ad35129c-ea28-5f94-b1b6-ccdc503932f2
DOI: 10.1101/130070

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