Article

Biophysical Modeling Uncovers Transcription Factor and Nucleosome Binding on Single DNA Molecules

2025-05-16

Abstract excerpt

Gene regulation in eukaryotes emerges from a dynamic interplay between transcription factors (TFs), nucleosomes, and RNA Polymerase II (Pol II), whose competitive and cooperative binding shapes DNA accessibility and transcriptional output. Single-molecule footprinting (SMF) and long-read chromatin accessibility assays such as Fiber-seq now capture these interactions at nucleotide resolution on individual DNA molec...

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Literature Corpus work: e4bafa10-2044-5827-b427-c1a11f88ee9f
DOI: 10.1101/2025.05.13.653852

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