Article

Gene structure heterogeneity drives transcription noise within human chromosomes

2022-06-09

Abstract excerpt

Classical observations have long suggested there is a link between 3D gene structure and transcription 1–4 . However, due to the many factors regulating gene expression, and to the challenge of visualizing DNA and chromatin dynamics at the same time in living cells, this hypothesis has been difficult to quantitatively test experimentally. Here we take an orthogonal approach and use computer simulations, based on...

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Literature Corpus work: 71fa12ba-3092-5f92-a995-dc1b8f089161
DOI: 10.1101/2022.06.09.495447

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