Article

Genome structure mapping with high-resolution 3D genomics and deep learning

2025-05-07

Abstract excerpt

Gene expression is often regulated by distal enhancers through cell-type-specific 3D looping interactions, but compre-hensive mapping of these interactions across cell types is experimentally intractable. To address this gap, we introduce an integrated approach where we generate ultra-deep Region Capture Micro-C (RCMC) and Micro-C data specifically designed for state-of-the-art deep learning architectures. We deve...

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Literature Corpus work: 41453a2f-3129-5ae1-97f0-f38e9c69d2c0
DOI: 10.1101/2025.05.06.650874

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