Article

Parkinson-associated <i>SNCA</i> enhancer variants revealed by open chromatin in mouse dopamine neurons

2018-07-08

Abstract excerpt

<h4>ABSTRACT</h4> The progressive loss of midbrain (MB) dopaminergic (DA) neurons defines the motor features of Parkinson disease (PD) and modulation of risk by common variation in PD has been well established through GWAS. Anticipating that a fraction of PD-associated genetic variation mediates their effects within this neuronal population, we acquired open chromatin signatures of purified embryonic mouse MB DA...

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Literature Corpus work: d2015553-28fa-5973-90fd-3b84fc017c6f
DOI: 10.1101/364257

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