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Identification of Parkinson’s disease-associated regulatory variants in human dopaminergic neurons reveals modulators of <i>SCARB2</i> and <i>BAG3</i> expression

2026-03-27

Abstract excerpt

A hallmark of Parkinson’s disease (PD) is the degeneration of midbrain dopaminergic neurons (mDANs). Genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) associated with PD, but causal variants and mechanisms remain unknown. Many PD-associated SNPs reside in regulatory regions, where they may disrupt transcription factor binding sites (TFBS) and alter gene expression. To as...

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Literature Corpus work
57b5ff6f-025c-53c3-8ee6-b7fb3691a012
DOI
10.64898/2026.03.26.714241
Open publication

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Identification of Parkinson’s disease-associated regulatory variants in human dopaminergic neurons reveals modulators of <i>SCARB2</i> and <i>BAG3</i> expressionDOI 10.64898/2026.03.26.714241
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