Article

Modeling <i>cis</i> -regulatory variation in human brain enhancers across a large Parkinson’s Disease cohort

2026-03-19

Abstract excerpt

Genome-wide association studies (GWAS) have linked more than a hundred non-coding genomic loci to Parkinson’s disease (PD) risk. Deciphering their functional impact on gene regulation requires cell type-aware modeling approaches to assess the effects of sequence variation on enhancer function and target gene expression. To address this challenge, we generated a comprehensive matched dataset from 190 human donors (...

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Literature Corpus work: 52df8879-4f0e-52d0-9109-e7c724a9bd49
DOI: 10.64898/2026.03.15.711881

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