Article

Massive-scale single-nucleus multi-omics identifies novel rare noncoding drivers of Parkinson’s disease

2026-03-05

Abstract excerpt

Most genetic variants contributing to complex diseases reside in the noncoding genome. While common variants uncovered by genome-wide association studies often fail to explain much of the observed heritability of these diseases, rare variants often have higher effect sizes and cumulatively explain a larger portion of heritability. However, rare variants, particularly rare noncoding variants, have remained under-ch...

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Literature Corpus work: 7085fc87-50af-52be-8492-bb4c5e21f32f
DOI: 10.64898/2026.03.05.709922

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