Article

Neuronal titration of <i>Snca</i> via enhancer disruption mitigates disease onset in a Parkinson’s disease mouse model

2025-04-15

Abstract excerpt

<h4>ABSTRACT</h4> α-synuclein ( SNCA ) is the greatest genetic risk factor for sporadic Parkinson’s Disease (PD). Misfolding and overexpression of SNCA underlie pathognomonic features of PD, including SNCA aggregates and midbrain dopaminergic (mbDA) neurodegeneration. We recently identified an SNCA intronic sequence that harbors variation associated with PD risk and demonstrated its role as a neuronal cis-regul...

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Literature Corpus work: b4074dbd-9ab9-5d0a-b893-76be2e208e0d
DOI: 10.1101/2025.04.09.648026

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