Article

<i>cis</i> -Regulatory Chromatin Contacts in Neural Cells Reveal Contributions of Genetic Variants to Complex Neurological Disorders

2018-12-13

Abstract excerpt

Mutations in gene regulatory elements have been associated with a wide range of complex neurological disorders. However, due to their inherent cell type-specificity and difficulties in characterizing their regulatory targets, our ability to identify causal genetic variants has remained limited. To address these constraints, we perform integrative analysis of chromatin interactions using promoter capture Hi-C (pcHi...

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Literature Corpus work: 3a174dda-4a72-5a31-8960-b7430df13de2
DOI: 10.1101/494450

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