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Article

Parkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expression.

Nature - 5 May 2016

Soldner Frank, Stelzer Yonatan, Shivalila Chikdu S, Abraham Brian J, Latourelle Jeanne C, Barrasa M Inmaculada, Goldmann Johanna, Myers Richard H, Young Richard A, Jaenisch Rudolf

Abstract excerpt

Genome-wide association studies (GWAS) have identified numerous genetic variants associated with complex diseases, but mechanistic insights are impeded by a lack of understanding of how specific risk variants functionally contribute to the underlying pathogenesis. It has been proposed that cis-acting effects of non-coding risk variants on gene expression are a major factor for phenotypic variation of complex...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27096366
DOI: 10.1038/nature17939
PMCID: PMC5042324

Genes

SNCA
EMX2

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