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Article

Parkinson's disease genetic risk in a midbrain neuronal cell line.

Neurobiology of disease - 1 Jun 2018

Pierce Steven E, Tyson Trevor, Booms Alix, Prahl Jordan, Coetzee Gerhard A

Abstract excerpt

In genome-wide association studies of complex diseases, many risk polymorphisms are found to lie in non-coding DNA and likely confer risk through allele-dependent differences in gene regulatory elements. However, because distal regulatory elements can alter gene expression at various distances on linear DNA, the identity of relevant genes is unknown for most risk loci. In Parkinson's disease, at least some...

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PMID: 29486295
DOI: 10.1016/j.nbd.2018.02.007

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CTCF

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