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Article

Common genetic variants associated with Parkinson's disease display widespread signature of epigenetic plasticity.

Scientific reports - 5 Dec 2019

Sharma Amit, Osato Naoki, Liu Hongde, Asthana Shailendra, Dakal Tikam Chand, Ambrosini Giovanna, Bucher Philipp, Schmitt Ina, Wüllner Ullrich

Abstract excerpt

Parkinson disease (PD) is characterized by a pivotal progressive loss of substantia nigra dopaminergic neurons and aggregation of α-synuclein protein encoded by the SNCA gene. Genome-wide association studies identified almost 100 sequence variants linked to PD in SNCA. However, the consequences of this genetic variability are rather unclear. Herein, our analysis on selective single nucleotide polymorphisms (SNPs)...

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Identifiers

PMID: 31804560
DOI: 10.1038/s41598-019-54865-w
PMCID: PMC6895091

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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