Article

Multiregional single-cell profiling reveals shared and specialized cellular vulnerability in Alzheimer’s disease

2026-07-02

Abstract excerpt

Alzheimer’s disease (AD) is defined and staged by the stereotyped, progressive accumulation of amyloid-beta (Aβ) plaques and hyperphosphorylated tau (pTau) tangles across brain regions. These regions differ substantially in their architecture and function but share largely conserved cellular composition, with some regional specialization. As pathology accumulates, specific neurons are lost and non-neuronal cells s...

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Literature Corpus work: d182c807-01b5-5c60-a72e-8751267930e7
DOI: 10.64898/2026.07.01.734821

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