Article

Integrated multimodal cell atlas of Alzheimer’s disease

2023-05-23

Abstract excerpt

<title>Abstract</title> <p>Alzheimer’s disease (AD) is the most common cause of dementia in older adults. Neuropathological and imaging studies have demonstrated a progressive stereotyped accumulation of protein aggregates, but the underlying molecular and cellular mechanisms driving AD progression and vulnerable cell populations affected by disease remain coarsely understood. The current study harnesses the BRAI...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9edcc1d5-bd39-5864-aefc-b6e7b070b5e9
DOI: 10.21203/rs.3.rs-2921860/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrated multimodal cell atlas of Alzheimer’s diseaseDOI 10.21203/rs.3.rs-2921860/v1Read

Integrated multimodal cell atlas of Alzheimer’s diseaseSemantic proximity Read

Multiregional single-cell profiling reveals shared and specialized cellular vulnerability in Alzheimer’s diseaseSemantic proximity Read

Distinctive whole-brain cell types predict tissue damage patterns in thirteen neurodegenerative conditionsSemantic proximity Read

Distinctive Whole-brain Cell Types Predict Tissue Damage Patterns in Thirteen Neurodegenerative ConditionsSemantic proximity Read

Single-nucleus and spatial transcriptomic profiling of human temporal cortex and white matter reveals novel associations with AD pathologySemantic proximity Read

Molecular and cellular pathology of monogenic Alzheimer’s disease at single cell resolutionSemantic proximity Read

Single-cell atlas of transcriptomic vulnerability across multiple neurodegenerative and neuropsychiatric diseasesSemantic proximity Read

The Caudate Nucleus Exhibits Distinct Pathology and Cell Type-Specific Responses Across Alzheimer’s DiseaseSemantic proximity Read

A single cell brain atlas in human Alzheimer’s diseaseSemantic proximity Read

Single-nucleus transcriptomics identifies a shared vulnerable excitatory neuronal population across typical and atypical Alzheimer’s diseaseSemantic proximity Read

Cell type-specific associations with Alzheimer’s Disease conserved across racial and ethnic groupsSemantic proximity Read

Single-cell anatomical analysis of human hippocampus and entorhinal cortex uncovers early-stage molecular pathology in Alzheimer’s diseaseSemantic proximity Read