Article

Single-nucleus transcriptomics identifies a shared vulnerable excitatory neuronal population across typical and atypical Alzheimer’s disease

2026-04-01

Abstract excerpt

<h4> A bstract </h4> Alzheimer’s disease (AD) presents with substantial clinical and anatomical heterogeneity, including both typical amnestic and atypical variants such as posterior cortical atrophy and logopenic primary progressive aphasia. Although neurofibrillary tangle (NFT) burden is a defining pathological feature of AD, its regional distribution varies across clinical phenotypes, suggesting that selecti...

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Literature Corpus work: 8bbe63d1-13a6-5d3a-bf3a-2724c13ff982
DOI: 10.64898/2026.03.30.715299

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