Article

Molecular and cellular pathology of monogenic Alzheimer’s disease at single cell resolution

2020-07-14

Abstract excerpt

Cell and molecular biology analyses of sporadic Alzheimer’s disease brain are confounded by clinical variability, ageing and genetic heterogeneity. Therefore, we used single-nucleus RNA sequencing to characterize cell composition and gene expression in the cerebral cortex in early-onset, monogenic Alzheimer’s disease. Constructing a cellular atlas of frontal cortex from 8 monogenic AD individuals and 8 matched con...

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Literature Corpus work: cd6893ce-44cd-52bb-a403-6c700da7cb69
DOI: 10.1101/2020.07.14.202317

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