Article

Single-cell atlas of transcriptomic vulnerability across multiple neurodegenerative and neuropsychiatric diseases

2024-11-04

Abstract excerpt

Neurodegenerative and neuropsychiatric diseases impose a significant societal and public health burden. However, our understanding of the molecular mechanisms underlying these highly complex conditions remains limited. To gain deeper insights into the etiology of different brain diseases, we used specimens from 1,494 unique donors to generate a population-scale single-cell transcriptomic atlas of the human dorsola...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9827619d-25f4-5e43-bf77-7dbf7b300580
DOI: 10.1101/2024.10.31.24316513

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell atlas of transcriptomic vulnerability across multiple neurodegenerative and neuropsychiatric diseasesDOI 10.1101/2024.10.31.24316513Read

Decoding cell-type-specific alterations in Alzheimer’s disease through scRNA-seq and network analysisSemantic proximity Read

Comparative mapping of single-cell transcriptomic landscapes in neurodegenerative diseasesSemantic proximity Read

Single-cell machine learning uncovers genetically anchored, cell-type specific programs of Alzheimer’s diseaseSemantic proximity Read

Mapping Alzheimer′s neuropathology signatures to the whole brain transcriptome using machine learning data fusionSemantic proximity Read

Multiregional single-cell profiling reveals shared and specialized cellular vulnerability in Alzheimer’s diseaseSemantic proximity Read

Brain transcriptomic profiling reveals common alterations across neurodegenerative and psychiatric disordersSemantic proximity Read

Brain transcriptomic profiling reveals common alterations across neurodegenerative and psychiatric disordersSemantic proximity Read

Disease-specific selective vulnerability and neuroimmune pathways in dementia revealed by single cell genomicsSemantic proximity Read

The Alzheimer’s disease neurodegenerative cascade reconstructed in human L2/3 excitatory neuronsSemantic proximity Read

Cell type-specific associations with Alzheimer’s Disease conserved across racial and ethnic groupsSemantic proximity Read

Human brain single nucleus cell type enrichments in neurodegenerative diseasesSemantic proximity Read

Molecular and cellular pathology of monogenic Alzheimer’s disease at single cell resolutionSemantic proximity Read