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A Scalable Human Brain Cell Atlas Foundation Model Dissects the Cellular Immune Codes and Cognitive Resilience

2025-07-08

Abstract excerpt

<title>Abstract</title> <p>The biological basis of resilience to cognitive decline and Alzheimer’s disease (AD) remains unclear, hindering the development of effective interventions for brain health. Here, we present the largest human brain single-nucleus RNA-seq atlas to date (~14 million nuclei across 31 brain regions from 2,239 deeply phenotyped postmortem samples, including cognitively normal (CN), AD (clinic...

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Literature Corpus work
d26a8014-5396-5378-a52b-26bf1046ed9f
DOI
10.21203/rs.3.rs-6986171/v1
Open publication

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