Article

The Alzheimer’s disease neurodegenerative cascade reconstructed in human L2/3 excitatory neurons

2026-04-15

Abstract excerpt

Identifying the molecular cascade underlying neuronal degeneration in Alzheimer’s disease has been hampered by cellular heterogeneity and the limitations of donor-level classification. By integrating 851,682 cortical layer 2 and 3 excitatory neuron transcriptomes from 557 individuals across four independent snRNA-seq datasets of the human prefrontal cortex, we reconstruct neuronal degeneration as a continuous, sta...

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Literature Corpus work: c074ed36-5f17-5fca-9014-c939fff0db19
DOI: 10.64898/2026.04.14.718430

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