Article

Early Alzheimer’s disease pathology in human cortex is associated with a transient phase of distinct cell states

2023-06-05

Abstract excerpt

<h4>Summary</h4> Cellular perturbations underlying Alzheimer’s disease are primarily studied in human postmortem samples and model organisms. Here we generated a single-nucleus atlas from a rare cohort of cortical biopsies from living individuals with varying degrees of Alzheimer’s disease pathology. We next performed a systematic cross-disease and cross-species integrative analysis to identify a set of cell stat...

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Literature Corpus work: 2851720f-5301-50bb-8f42-c2d5b7d0999f
DOI: 10.1101/2023.06.03.543569

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