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The Caudate Nucleus Exhibits Distinct Pathology and Cell Type-Specific Responses Across Alzheimer’s Disease

2026-01-10

Abstract excerpt

<h4>SUMMARY</h4> Aβ presence in the caudate nucleus (Ca) partially defines Thal stage III in Alzheimer’s disease (AD), but little is known about AD’s cellular impact on the region. Leveraging a public basal ganglia taxonomy of cellular populations, we generated a cellular resolution atlas of AD-associated pathological changes in Ca. Unlike cortex, we found that Ca AD pathology is dominated by two key features: ph...

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Literature Corpus work
668e8181-02cd-563d-8ca3-168b5df872e4
DOI
10.64898/2026.01.10.694705
Open publication

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The Caudate Nucleus Exhibits Distinct Pathology and Cell Type-Specific Responses Across Alzheimer’s DiseaseDOI 10.64898/2026.01.10.694705
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