Article

Structural Basis for OAS2 Regulation and its Antiviral Function

2025-01-28

Abstract excerpt

<h4>Summary</h4> Oligoadenylate synthetase (OAS) proteins are immune sensors for double-stranded RNA and critical for restricting viruses. OAS2 comprises two OAS domains, only one of which can synthesize 2’-5’-oligoadenylates for RNase L activation. Existing structures of OAS1 provide a model for enzyme activation, but do not explain how multiple OAS domains discriminate RNA length. Here, we discover that OAS2 ex...

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Literature Corpus work: d094f970-82cf-5527-acde-87fb6c0716a2
DOI: 10.1101/2025.01.28.635220

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