Article
A mutation in the viral sensor 2'-5'-oligoadenylate synthetase 2 causes failure of lactation.
PLoS genetics - 1 Nov 2017
Oakes Samantha R, Gallego-Ortega David, Stanford Prudence M, Junankar Simon, Au Wendy Wing Yee, Kikhtyak Zoya, von Korff Anita, Sergio Claudio M, Law Andrew M K, Castillo Lesley E, Allerdice Stephanie L, Young Adelaide I J, Piggin Catherine, Whittle Belinda, Bertram Edward, Naylor Matthew J, Roden Daniel L, Donovan Jesse, Korennykh Alexei, Goodnow Christopher C, O'Bryan Moira K, Ormandy Christopher J
Abstract excerpt
We identified a non-synonymous mutation in Oas2 (I405N), a sensor of viral double-stranded RNA, from an ENU-mutagenesis screen designed to discover new genes involved in mammary development. The mutation caused post-partum failure of lactation in healthy mice with otherwise normally developed mammary glands, characterized by greatly reduced milk protein synthesis coupled with epithelial cell death, inhibition of...
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