Article

DAZAP2 functions as a pan-coronavirus restriction factor by inhibiting viral entry and genomic replication

2025-02-07

Abstract excerpt

<h4>ABSTRACT</h4> The SARS-CoV-2 pandemic and the emergence of novel variants underscore the need to understand host-virus interactions and identify host factors that restrict viral infection. Here, we perform a genome-wide CRISPR knockout screen to identify host restriction factors for SARS-CoV-2, revealing DAZAP2 as a potent antiviral gene. DAZAP2, previously implicated in SARS-CoV-2 restriction, is found to in...

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Literature Corpus work: 42efa113-7338-58c6-bb92-0c4a36bbd2f9
DOI: 10.1101/2025.02.04.636569

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